Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS.

ABSTRACT: It is well-established that adolescents' temperament trajectories predict future psychopathology. Less well understood is how temperament traits co-develop from adolescence to young adulthood. We characterized how youths' trajectories of effortful control, frustration, affiliation, and shyness formed multi-trajectory groups and examined their associations with adulthood psychopathology and polygenic risk scores (PRS). Participants were drawn from a larger longitudinal cohort (N = 1412). Effortful control, frustration, affiliation, and shyness were measured four times from ages 10-23. Adulthood internalizing and externalizing problems were measured at ages 24-27. PRS for externalizing problems and major depressive disorder were calculated. Group-based multi-trajectory analyses showed

SUBMITTER: Wang FL 

PROVIDER: S-EPMC12752481 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature