Myc and Tor drive growth and cell competition in the regeneration blastema of Drosophila wing imaginal discs.

ABSTRACT: During the regeneration of injured or lost tissues, the regeneration blastema serves as a hub for robust growth. Drosophila imaginal discs are a genetically tractable and simple model system for the study of regeneration and organization of this regrowth. Key signals that contribute to regenerative growth in these discs, such as reactive oxygen species, Wnt/Wg, JNK, p38, JAK/STAT and the Hippo pathway, have been identified. However, a detailed exploration of the spatial organization of regrowth, the factors that directly drive this growth, and the consequences of activating drivers of regeneration has not been undertaken. Here, we find that regenerative growth in imaginal discs is controlled by the transcription factor Myc and by Tor signaling, which drive proliferation and translation in

SUBMITTER: Hsu FT 

PROVIDER: S-EPMC12752512 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature