Compensatory action of different types of cis-regulatory elements buffers the striped expression of Drosophila pair-rule genes.

ABSTRACT: The striped expression of pair-rule genes in Drosophila embryos is a paradigm for understanding transcriptional control of development. Pair-rule striped expression is regulated by two types of cis-regulatory elements: stripe-specific elements respond to non-periodic cues in different regions of the embryo to establish individual stripes while 7-stripe elements simultaneously regulate all stripes, responding to pair-rule genes expressed in stripes. Here, we assess roles of stripe-specific versus 7-stripe elements for the pair-rule gene ftz. We show that loss of a ftz stripe 2 element is compensated by 7-stripe elements, even though they respond to different spatiotemporal cues. We next investigate whether similar rules apply to the classic eve stripe2 element. Animals homozygous for a geno

SUBMITTER: Fischer MD 

PROVIDER: S-EPMC12752513 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature