The risk of cardiovascular death in systemic immune-mediated diseases: A systematic review and meta-analysis.

ABSTRACT:

Aims

To perform a systematic review and meta-analysis assessing the association between systemic immune-mediated diseases (SIDs) and cardiovascular death.

Methods

A systematic search of PubMed, Cochrane Library, and ClinicalTrials.gov was performed from inception through September 28, 2024. Effect measures for cardiovascular death were extracted for overall SIDs and for individual subtypes. Pre-specified sensitivity analyses and meta-regression by age, sex, and follow-up duration were conducted. The study followed MOOSE guidelines (PROSPERO-ID: CRD420251033612).

Results

From 76,531 records, 39 observational studies comprising 171,748 patients were included. SIDs were associated with higher cardiovascular mortality (HR 1.26; 95 % CI 1.09-1.47; p = 0.002), consis

SUBMITTER: Figliozzi S 

PROVIDER: S-EPMC12752519 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature