Protein CoAlation is regulated by and integrated with growth factor signalling and the cellular antioxidant response.

ABSTRACT: Coenzyme A (CoA) is an essential cellular cofactor and low molecular weight thiol (LMWT) that forms metabolically active thioesters involved in various metabolic pathways. Recently, CoA has emerged as an important antioxidant due to its covalent attachment to protein cysteine thiols in response to oxidative and metabolic stress. This modification, termed CoAlation, protects proteins from over-oxidation and can alter protein activity, subcellular localisation and conformation in eukaryotic and prokaryotic cells. However, whether protein CoAlation is implicated in cellular transformation or adaptation to oxidative stress in cancer cells is unknown. Cancer cells are known to harbour high basal reactive oxygen species (ROS) levels and to mitigate oxidative stress by deploying antioxidant enzym

SUBMITTER: Gribbon D 

PROVIDER: S-EPMC12752523 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature