Personalized Cancer Immunotherapy Boosted by cGAS-STING-Targeted Nanovaccines in Combination With Nutrient Modulation.

ABSTRACT: Cyclic dinucleotides, which act as agonists for the stimulator of interferon genes (STING), are pivotal in stimulating both adaptive and innate immune reactions for advancing cancer immunotherapy. However, their therapeutic potential is hampered by inherent limitations, including susceptible degradation and inefficient delivery. Herein, we design genetically engineered bacteria (2'3'[e-mail]) capable of producing 2'3'-cGAMP in the cytoplasm and then fabricate personalized nanovaccines (nECTs) by assembling 2'3'[e-mail] with autologous tumor antigens instead of complicated chemical synthesis. Our in vitro analysis confirms that nECTs are capable of potently stimulating dendritic cell activity and amplifying the cross-presentation of antigens by leveraging the STING s

SUBMITTER: Huang W 

PROVIDER: S-EPMC12752548 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature