CircLRBA Promotes Epithelial-Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1.

ABSTRACT: Breast cancer (BC) is a malignant tumor with the highest incidence in women. Metastasis is the leading cause of BC-related death. Circular RNAs (circRNAs) play important roles in cancer progression and metastasis, therefore exploring its specific mechanism in BC metastasis has high value. However, the biological roles and potential mechanism of circRNAs in BC remain unclear. Here, a highly expressed circRNA circLRBA in BC tissues is identified using high-throughput sequencing, which is associated with pathological stage and poor overall survival. Functional assays show that circLRBA facilitates BC cell proliferation, invasion, migration, docetaxel (DTX) resistance, and inhibits the infiltration of CD8+ T cell in vitro and in vivo. Whereas circLRBA knockdown reveals opposite roles. Mechanis

SUBMITTER: Wang X 

PROVIDER: S-EPMC12752550 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature