ERβ/circAHNAK Axis Inhibits USP10-FMR1 Deubiquitination to Prevent m⁶A-Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma.

ABSTRACT: Estrogen receptor β (ERβ), a nuclear hormone receptor, plays multifaceted roles in tumorigenesis, including transcriptional regulation and noncoding RNA signaling. In clear cell renal cell carcinoma (ccRCC), ERβ is frequently overexpressed and associated with enhanced angiogenesis, a hallmark of aggressive tumor progression. However, the mechanisms linking ERβ signaling to the post-transcriptional and post-translational regulation of angiogenic drivers remain poorly defined. In this study, circAHNAK is identified as a direct downstream effector of ERβ and is significantly upregulated in ccRCC tissues. Elevated circAHNAK in ccRCC cells promotes angiogenesis-related phenotypes in HUVECs by stabilizing ADAM17, a metalloprotease known to facilitate tumor angiogenesis. Mechanistically, ERβ enha

SUBMITTER: Xu C 

PROVIDER: S-EPMC12752611 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature