Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task-related Neuronal Activity.

ABSTRACT: Motor learning induces oligodendrocyte (OL) dynamics/plasticity during learning. However, it remains unclear whether different adaptive OL dynamics are required for different phases of motor learning and how they regulate neuronal activity. Here, we showed reduced oligodendrogenesis accompanied by elongated node length in the contra-rostral forelimb area (cRFA) motor cortex during learning of the forelimb reaching task, both of which correlate with the learning performance. However, we observed increased oligodendrogenesis during the motor memory consolidation phase, which also correlates with the motor skill maintenance. Strikingly, Myrf conditional knockout (OPC-Myrf-cKO) mice, in which oligodendrogenesis can be artificially blocked, showed improved learning performance along with increa

SUBMITTER: Wang S 

PROVIDER: S-EPMC12752644 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature