Cell Contractile Force-Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds.

ABSTRACT: Tissue morphogenesis is a critical aspect of tissue development. Recent advances in 4D cell scaffolds have shown promise for modeling morphogenetic processes. While current 4D systems often rely on external stimuli, they frequently overlook the role of intrinsic cell-generated forces, such as cell contractile forces (CCFs), in driving tissue morphogenesis. The paradox between the inherently weak nature of CCFs and the robustness of tissue scaffolds presents a significant challenge in achieving effective shape transformations. In this study, an easily printable, freestanding, cell-laden hydrogel platform is designed to harness CCFs for 4D shape morphing. These hydrogels initially provide mechanical support to maintain structural integrity, followed by rapid degradation that amplifies CCFs t

SUBMITTER: Ding A 

PROVIDER: S-EPMC12752645 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature