Enhanced Antibacterial Efficacy of Copper Single-Atom Catalysts on a Two-Dimensional Boron Nitride Platform.

ABSTRACT: Copper-based antibacterial systems leverage reactive oxygen species (ROS) for effective pathogen control but are limited by issues such as cytotoxicity and resistance due to Cu ion release. By anchoring copper single-atom catalysts (Cu SACs) on biocompatible boron nitride (BN) nanosheets, we create a stable, high-efficiency antibacterial platform that minimizes Cu-ion-induced cytotoxicity and bacterial resistance. This configuration maximizes metal utilization and enhances photocatalytic efficiency for ROS generation, including hydroxyl radicals and superoxide anions. The defect-assisted covalent bonding between Cu and BN ensures stable coordination, preventing metal ion dissolution. First-principles quantum calculations at the level of density functional theory (DFT) provided critical ins

SUBMITTER: Li W 

PROVIDER: S-EPMC12752704 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature