PD-1 blockade enhances functional vaccine-induced HIV-1 CD8⁺ T-cell responses in PWH receiving early ART.

ABSTRACT:

Background

Immunotherapeutic strategies combining Immune checkpoint blockade (ICB) and therapeutic T-cell vaccination hold promise to enhance HIV-1 remission in people with HIV (PWH). While T-cell vaccination alone has shown limited efficacy, ICB may potentiate vaccine-induced T-cell responses. We investigate the functional impact of ICB on vaccine-induced HIV-1-specific CD8⁺ T-cell responses using relevant samples from PWH receiving early ART and T-cell vaccination.

Methods

We conducted comparative laboratory studies on PD-1 and TIM-3 blockade using biological samples from PWH on early ART and T-cell vaccination (Etvac), or without vaccination (Et) from the BCN01 trial, a phase I non-randomised, multicenter therapeutic HIV-1 vaccine study. Also, we included sampl

SUBMITTER: Marin M 

PROVIDER: S-EPMC12752766 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature