Sex-specific interaction effects of Syntaxin 1A coexpression network and childhood trauma on adult depressive symptoms.

ABSTRACT:

Background

Disruptions in synaptic function and exposure to early life trauma are both implicated in the development of depression, though the underlying mechanisms remain poorly understood.

Methods

To investigate this relationship, we developed an expression-based polygenic score (ePRS) that captures individual variations in the expression of genes co-expressed with the synaptic protein Syntaxin 1A (STX1A) in the prefrontal cortex (PFC). This polygenic score allows us to explore the impact of variations on synaptic function and childhood trauma on the susceptibility to depressive symptoms in adulthood.

Findings

Our findings indicate that the PFC-ePRS-STX1A score moderates the effects of childhood trauma on the diagnosis of depression in adult females from the UK Biob

SUBMITTER: Arcego DM 

PROVIDER: S-EPMC12752767 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature