Polymer Coated Iron-Boron and Gold-Iron Alloy Nanoparticles for Magnetic Resonance Imaging and Near Infrared Photothermal Applications.

ABSTRACT: Iron alloy nanoparticles (IA NPs) are appealing tools for nanomedicine because of their composition-dependent properties, including magnetism, near-infrared (NIR) absorption, radiosensitization, and biodegradability. However, NP stability in biological environments is a limiting factor in their use. The effective surface modification of IA NPs using hydrophilic biocompatible molecules is the only strategy to optimize the half-life in blood circulation, biodistribution, cellular absorption, and bioaccumulation. Here, IA NPs based on iron-boron (Fe-B) and gold-iron (Au-Fe) were surface stabilized using various polyethylene glycol derivatives or polyvinylpyrrolidone, which were then combined with silanes and citric acid to determine the best formulation in terms of nanometric size, biocompati

SUBMITTER: Bissoli M 

PROVIDER: S-EPMC12752774 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature