Exploratory Research on the Urine Proteome in Patients With Diabetic Peripheral Neuropathy.

ABSTRACT: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes and there are currently no biomarkers for DPN in clinical practice. The objective of this study was to explore the diagnostic value of urine for diseases and discover potential markers. Urinary proteomics was used to analyze urine samples from patients with DPN and healthy individuals. Quantitative analysis of mass spectrometry data was performed using both group-based and paired individual analysis strategies. A total of 2611 proteins were identified, of which 1759 were quantifiable, and 312 proteins showed significant differences (fold change > 2, adjusted p value < 0.01), with 239 decreased and 73 increased. A random grouping cross-validation strategy was employed to evaluate the differentially expressed pr

SUBMITTER: Wei L 

PROVIDER: S-EPMC12752815 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature