Heparin-Induced Thrombocytopenia and Thrombosis in Patients With or Without a Thrombophilia Background: A Systematic Review Involved 602 Cases.

ABSTRACT:

Background

Heparin-induced thrombocytopenia (HIT), often accompanied by thrombotic events and collectively referred to as heparin-induced thrombocytopenia and thrombosis (HITT), is worthy of attention. Herein, we analyzed the features of HITT in patients with or without a thrombophilia background present prior to heparin exposure, aiming to identify and customize treatment.

Methods

We searched PubMed and EMBASE to identify studies published up to November 2024, via the keywords "heparin," "thrombocytopenia," "thrombosis," and "thrombophilia." Case series and reports with confirmed HITT were included.

Results

A total of 602 patients (277 males and 325 females with a mean age of 57.00 ± 17.20 years), reported in 481 papers, were carefully analyzed. The median time of th

SUBMITTER: Han G 

PROVIDER: S-EPMC12752825 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature