PFKL Inhibition by DT-13: A Novel Approach to Combat Hepatocellular Carcinoma.

ABSTRACT: Aerobic glycolysis modulates proliferation, apoptosis, immune evasion, and targeted drug resistance in hepatocellular carcinoma (HCC) patients. Therefore, inhibiting aerobic glycolysis could represent a novel chemotherapeutic strategy for HCC. The effects of Liriope muscari Baily's Saponin C (DT-13), a novel compound isolated from the traditional Chinese medicine Liriope muscari (Decne) Baily, on HCC and its underlying mechanism remain unknown. This study revealed that DT-13 induces apoptosis and inhibits the in vivo and in vitro proliferation of HCC cells. Furthermore, DT-13 significantly reduced glucose consumption and lactate production. Moreover, it was observed that DT-13 could inhibit Phosphofructokinase-1 liver (PFKL) type via c-myc signaling to modulate the aerobic gl

SUBMITTER: Yu Q 

PROVIDER: S-EPMC12752837 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature