Association Between Discordance of Disease Activity Indices and Quantitative Sensory Testing Measures of Nociplastic Pain in Patients With Rheumatoid Arthritis.

ABSTRACT:

Objective

This study investigates the association between discordance in commonly collected clinical indicators of rheumatoid arthritis (RA) disease activity and abnormalities in quantitative sensory testing (QST) observed in individuals with nociplastic pain. The goal is to identify low-burden methods of assessing nociplastic pain in rheumatology practice.

Methods

Data from 225 patients with active RA were included for cross-sectional analyses. Measures of discordance in disease activity were as follows: (1) tender-swollen joint count difference (TSJD), (2) proportion of subjective components to the total Disease Activity Score in 28 joints (DAS28-P), and (3) patient global assessment of disease activity minus evaluator global assessment of Disease Activity (PtGA - EGA). QS

SUBMITTER: Lin CP 

PROVIDER: S-EPMC12752918 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature