Genomic insights into the expansion of meropenem-resistant GPSC1-CC320 Streptococcus pneumoniae serotype 19A isolates from children under 5 years of age with invasive infections, 2018-2024.

ABSTRACT: The global rise of multidrug-resistant (MDR) Streptococcus pneumoniae serotype 19A despite widespread pneumococcal conjugate vaccine (PCV) use poses an emerging challenge for pediatric infectious disease control. In South Korea, the detection of serotype 19A initially declined following PCV13 implementation, but it has recently re-emerged, raising concerns over the evolution and persistence of high-risk clones. We investigated invasive serotype 19A isolates recovered from children under five years of age between 2018 and 2024. Antimicrobial susceptibility testing and whole-genome sequencing (WGS) were conducted to characterize resistance mechanisms, clonal structure, and phylogenetic relationships. Among the 104 invasive pneumococcal isolates, 11 (10.6%) were identified as serotype 19A. Al

SUBMITTER: Lee J 

PROVIDER: S-EPMC12752945 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature