Gender differences in the association between pan-immune-inflammation value and probable depression: A cross-sectional study.

ABSTRACT: This study explored the non-linear relationship between pan-immune inflammation value (PIV) and probable depression using NHANES data (2005-2018, n = 27,049). Restricted cubic spline analysis identified an optimal PIV cutoff (5.74). Weighted logistic regression revealed that individuals with PIV > 5.74 had 14% higher risk of probable depression (OR=1.14, 95% CI:1.02-1.28). Gender-stratified analyses showed significant PIV and probable depression associations in females (OR=1.20, 95% CI:1.03-1.40) but not in males. In males, higher PIV interacted with age, education, and alcohol consumption to influence probable depression risk (interaction P < 0.05), whereas no such interactions occurred in females. The findings suggest PIV may serve as a sex-specific biomarker for probable depression risk

SUBMITTER: Yu D 

PROVIDER: S-EPMC12752952 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature