Association between triglyceride-glucose derived indices with cardiometabolic multimorbidity: Findings from the Atherosclerosis Risk in Communities study.

ABSTRACT:

Background

Cardiometabolic multimorbidity (CMM), characterized by the co-occurrence of diabetes mellitus (DM), stroke, and coronary heart disease (CHD), imposes substantial global health burden owing to its association with elevated mortality risk, reduced functional capacity, and increased healthcare costs. Despite its clinical importance, the value of insulin resistance (IR) and its surrogates, particularly triglyceride-glucose (TyG) indices combined with anthropometric measures, in predicting CMM remains underexplored.

Methods

In this study, we aimed to quantify the association between TyG-derived indices and incident CMM. For this purpose, we conducted a multivariate logistic regression analysis of data of the Atherosclerosis Risk in Communities (ARIC) study, deriving ad

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12752969 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature