Association between methylmalonic acid and Alpha-Klotho in American adults: A cross-sectional study.

ABSTRACT:

Objectives

Methylmalonic acid is a surrogate biomarker of mitochondrial dysfunction and oxidative stress. Serum soluble α-Klotho, as a key anti-aging factor, is regarded as one of the biomarkers of aging. The correlation between Methylmalonic Acid (MMA) and Alpha-Klotho (α-Klotho) remains uncertain. This study aims to explore the relationship between MMA and Alpha-Klothoα-Klotho in American adults.

Materials and methods

Based on the availability of complete biochemical assays for MMA and α-Klotho, we restricted our analyses to the 2011-2014 cycles of the National Health and Nutrition Examination Survey (NHANES), which included 5,216 eligible participants with comprehensive laboratory data. Due to the limited amount of data, there may be a selection bias. In this study, MMA s

SUBMITTER: Bao R 

PROVIDER: S-EPMC12752970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature