Exploring DNA methylation profiles in blood samples of canine gastrointestinal lymphoma.

ABSTRACT: Blood-based testing represents a valuable tool for the detection and monitoring of patient conditions in both human and veterinary medicine. When conventional tissue-based diagnosis is challenging, blood-derived measurements allow for minimally invasive testing. Recent studies across mammalian species, particularly in humans, have explored the use of DNA methylation from whole blood, revealing its potential to predict individual mortality and responses to environmental stresses. While it is well recognized that tumor lesions display altered epigenetic modifications across some mammalian species, little is known about how DNA methylation in blood, as an indirect tissue sample, reflects the status of individuals in dogs. In this study, we conducted whole genome bisulfite sequencing using who

SUBMITTER: Nakamura M 

PROVIDER: S-EPMC12752990 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature