Integrating stent design and microstructural characterization to improve clinical outcomes of bioresorbable stents.

ABSTRACT: Bioresorbable stents were conceived to revolutionize the treatment of cardiovascular diseases. However, their significant benefits were overshadowed by a higher clotting rate compared to permanent implants. This clinical failure is linked to strain-induced microstructural disruptions during fabrication and implantation, resulting in heterogeneous loss of structural integrity. The non-gradual loss of support, combined with faster, localized polymer deterioration, directly contributes to the clinical failure observed in bioresorbable stents. Leveraging this understanding marks a significant advancement toward their safe reintroduction. However, the extent to which a stent's stress distribution interacts with the polymer's microstructure remains understudied. This study advances the existing

SUBMITTER: Canalejo-Codina F 

PROVIDER: S-EPMC12753002 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature