Additive effect of type 2 diabetes mellitus, sarcopenia, and hypertension on cardiovascular disease and mortality: A national-wide cohort study from China.

ABSTRACT:

Introduction

The combined impact of type 2 diabetes mellitus (T2DM), sarcopenia, and hypertension on incident cardiovascular disease (CVD) and mortality remains inconclusive. This study aimed to evaluate the additive effect of these co-morbidities on CVD and all-cause mortality among Chinese adults aged 45 years and older.

Materials and methods

A total of 12,398 participants were enrolled in the China Health and Retirement Longitudinal Study. Participants were categorized based on their T2DM, sarcopenia, and hypertension status. The study outcomes included incident CVD (including heart disease and stroke) and all-cause mortality. Multivariable logistic regression models and population attributable fractions (PAFs) were employed to investigate the associations between the coe

SUBMITTER: Su M 

PROVIDER: S-EPMC12753039 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature