Early-pregnancy HDL-related inflammatory indices and risk of preeclampsia: A retrospective cohort study.

ABSTRACT:

Background

Preeclampsia (PE) is closely associated with dyslipidemia and inflammatory imbalance. High-density lipoprotein (HDL)-related inflammatory indices have demonstrated predictive potential in cardiovascular and metabolic diseases, but evidence regarding their role in PE remains limited.

Objective

This study aimed to investigate the associations between early-pregnancy HDL-related inflammatory indices, including the lymphocyte-to-HDL ratio (LHR), monocyte-to-HDL ratio (MHR), neutrophil-to-HDL ratio (NHR), and platelet-to-HDL ratio (PHR), and the risk of PE.

Methods

A total of 5,959 women with singleton pregnancies were retrospectively included. All participants underwent complete blood counts (CBC) and lipid profiling at 11-13 weeks of gestation, from which HDL-

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12753046 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature