Bat Dicer antiviral role and subcellular localization differ upon alphavirus infection in two distinct species.

ABSTRACT: Bats are reservoirs for many viruses that frequently cause epidemics in humans and animals. It is thus critical to better understand their immune system and mechanisms of antiviral immunity. Despite an increasing number of studies, much remains to be discovered about the molecular mechanisms that govern bat-virus interactions, especially given the large diversity of bat species. Dicer is a conserved ribonuclease with multiple activities that can modulate antiviral immunity, including the detection of viral RNA as part of the RNA interference (RNAi) pathway, the maturation of microRNAs, and the direct inhibition of innate immunity in mouse and human cells. In view of these complex activities of Dicer, we tested its antiviral activity in Myotis myotis nasal epithelial cells. Surprisingly, we

SUBMITTER: Gaucherand L 

PROVIDER: S-EPMC12753048 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature