Regulatory network rewiring drives strain-specific lipid accumulation response in Chlorella sorokiniana under nutrient starvation.

ABSTRACT: Microalgae modulate lipid metabolism in response to nutrient stress, offering a promising avenue for sustainable biofuel production. However, a mechanistic understanding of the transcriptional programs driving triacylglycerol (TAG) accumulation remains limited, particularly in non-model species. Here, we employ a systems-level approach to dissect the regulatory basis of TAG biosynthesis in two Chlorella sorokiniana strains exhibiting contrasting lipid accumulation phenotypes under nitrogen (N) and phosphorus (P) deprivation. Through physiological, metabolic, and transcriptomic analyses, we confirmed C. sorokiniana DOE1412 (CsDOE1412) as a high TAG-accumulator and C. sorokiniana UTEX1228 (Cs1228) as a low TAG-accumulator, providing a comparative framework for inferring transcriptional reg

SUBMITTER: Barrera-Duarte CC 

PROVIDER: S-EPMC12753097 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature