Etiology of Iridocorneal Endothelial Syndrome: Viral Infection and Immune Suppression.

ABSTRACT:

Purpose

Iridocorneal endothelial (ICE) syndrome is a rare ocular disease affecting the anterior segment, leading to cornea edema and glaucoma. Its unclear etiology limits clinical management to symptomatic interventions. This study uses diverse methodologies to explore potential viral sequences in patients' samples and to elucidate the transcriptomic profiles of ICE cells.

Methods

We used a convenience sampling method, including all eligible patients for analysis. We reviewed polymerase chain reaction (PCR) results for herpes viruses across all samples obtained from ICE syndrome patients at our institution. To further delve into potential pathogenic involvement, we used metagenomic sequencing and whole-genome sequencing techniques on samples. We used smart-seq2 RNA sequencin

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12753121 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature