FMRP restoration in parvalbumin interneurons: A circuit-specific improvement of visual learning in fragile X syndrome.

ABSTRACT: Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired sensory processing and learning disabilities, of which Fragile X syndrome (FX) is a leading genetic cause. Visual familiarity evokes persistent theta oscillations (4-8 Hz) in the primary visual cortex (V1) of mice, which are weaker and slower in Fmr1 KO mice correlating with the decreased excitatory synaptic drive onto fast-spiking interneurons. To test if loss of Fmr1 protein (FMRP) expression in parvalbumin-positive (PV+) fast-spiking interneurons is causal to impaired oscillations and learning, we restored FMRP selectively in PV+ interneurons (Fmr1cON/PV-Cre). Silicon probe recordings of V1 showed that targeted restoration rescued frequency and duration of oscillatory respons

SUBMITTER: Nareddula S 

PROVIDER: S-EPMC12753247 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature