Brain topology alteration in Alzheimer's disease brain networks: A multi-center study.

ABSTRACT: Alterations in brain network centrality are key features of Alzheimer's disease (AD) and may offer insights into the disruption of network organization underlying cognitive decline. We introduce a novel centrality metric, DomiRank, to characterize dominance-driven connectivity patterns in the human brain network, using a multi-center MRI dataset comprising 809 participants. Compared with conventional metrics, DomiRank centrality showed greater sensitivity in detecting AD-related network disruptions, particularly within the cingulate gyrus, precuneus, and subcortical hubs such as the basal ganglia-regions critical for cognition. Regional DomiRank alterations were significantly correlated with clinical cognitive scores, indicating their potential relevance to disease severity. Gene enrichmen

SUBMITTER: Ma L 

PROVIDER: S-EPMC12753252 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature