Recent advances in single-cell bioinformatics for inferring higher-order chromatin contact maps.

ABSTRACT: DNA, a large molecule located in the nucleus, carries essential genetic information, including gene loci and cis-regulatory elements. Despite its extensive length, DNA is compactly stored within the limited space of the nucleus due to its hierarchical three-dimensional (3D) organization. In this structure, DNA is organized into territories known as topologically associated domains (TADs). Within each TAD, numerous chromatin loops link promoters and enhancers across the genome. These loops and the interactions between promoters and enhancers are dynamically regulated, thereby controlling gene transcription activities. With the rapid advancements in single-cell genomics technologies, TAD boundaries and chromatin loops can now be observed at the level of individual cells, allowing researchers

SUBMITTER: Noh SK 

PROVIDER: S-EPMC12753332 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature