Levothyroxine dose prediction post-thyroidectomy for differentiated thyroid carcinoma.

ABSTRACT:

Objective

To address the overestimation of levothyroxine (L-T4) doses in conventional weight-based regimens for individuals who are overweight and obese, this study aimed to identify the most predictive body weight metrics and establish an optimized dosing model for accurate thyroid-stimulating hormone (TSH) suppression following total thyroidectomy in differentiated thyroid carcinoma (DTC).

Methods

This retrospective study included 385 patients with DTC treated at our institution between October 2019 and December 2024. Patients were stratified by TSH targets (A1: <0.1 mIU/L; A2: 0.1-0.5 mIU/L; A3: 0.5-2.0 mIU/L) and body mass index (BMI) according to Chinese criteria (normal: <24 kg/m²; overweight: 24-27.9 kg/m²; obesity: ≥28 kg/m²). Linear regression analysis was used to a

SUBMITTER: Ma L 

PROVIDER: S-EPMC12753355 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature