CALLY index predicts survival and surgical outcomes in colorectal cancer.

ABSTRACT:

Background

The prognostic evaluation of colorectal cancer (CRC) traditionally relies on TNM staging, which fails to incorporate host-related factors such as systemic inflammation, nutrition, and immunity. The C-reactive protein-albumin-lymphocyte (CALLY) index has recently been proposed as a novel biomarker integrating these domains.

Methods

We retrospectively analyzed 957 patients with CRC undergoing curative resection (2010-2020). The CALLY index was calculated from preoperative laboratory data. Patients were stratified into high- and low-CALLY groups using ROC-derived cutoffs. Associations with postoperative complications, overall survival (OS), and disease-free survival (DFS) were assessed and compared with other indices (mGPS, PNI, NLR, PLR, SII, CAR).

Results

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SUBMITTER: Zong Y 

PROVIDER: S-EPMC12753397 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature