<i>MGAT1</i> knockout in human dendritic cells enhance CD8⁺ T cell activation.

ABSTRACT: Dendritic cells (DCs) are crucial in regulating immune responses, making them a compelling target for immunotherapy. While DC vaccines have demonstrated safety and feasibility, their limited clinical efficacy underscores the need for strategies to enhance DC functionality. Emerging evidence highlights the regulatory roles of sialoglycans in DC biology, yet the structure-function relationships of other glycans remain poorly understood. To aid the understanding of DC glycobiology, we recently developed and validated a human model system based on genetically glycoengineered MUTZ-3-derived DCs and showed that ST6GAL1-mediated α2,6-sialylation specifically modulates CD4⁺ T cell activation. In this study, we knocked-out (KO) mannosyl (α-1,3-)-glycoprotein β-1,2-N-acetylglucosaminyltra

SUBMITTER: Blomberg AL 

PROVIDER: S-EPMC12753448 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature