Multi-center evaluation of Neurophet AQUA for brain MRI segmentation: T1 compared with FreeSurfer and T2-FLAIR compared with ground truth.

ABSTRACT:

Introduction

Accurate segmentation of brain regions in magnetic resonance imaging (MRI) is essential for diagnosing and managing neurological diseases. FreeSurfer is a widely used tool for brain MRI segmentation, but its limitations in speed and usability pose challenges in clinical practice. Neurophet AQUA, an advanced automated segmentation tool, aims to overcome these challenges by offering rapid and reliable segmentation. This study evaluates two segmentation pipelines: (1) a T1-based brain region segmentation pipeline, comparing the performance and reliability of Neurophet AQUA and FreeSurfer v7.3.2 using the standard recon-all pipeline in segmenting gray matter, white matter, and subcortical structures; and (2) a T2-FLAIR-based white matter lesion segmentation pipeline of Neu

SUBMITTER: Yu H 

PROVIDER: S-EPMC12753458 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature