Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review.

ABSTRACT:

Background

While excessive oral intake of clozapine is known to cause severe complications, this case report highlights that even conventional doses of clozapine ingested after alcohol consumption-without reaching toxic concentrations-can lead to the rare complication of rhabdomyolysis when synergistic effects occur between the two substances.

Case presentation

We report a case of a 39-year-old male patient who presented with impaired consciousness 1 day after consuming 500 g liquor followed by ingestion of 8 clozapine tablets (200 mg total). Toxicology screening upon admission indicated subtoxic levels of clozapine. Laboratory findings confirmed rhabdomyolysis, acute kidney injury, and myocardial damage. During hospitalization, the patient underwent hemopurification and flu

SUBMITTER: Zhou W 

PROVIDER: S-EPMC12753459 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature