Molecular Effects of Glucose on <i>MIR503HG</i>-Regulated Genes in Triple-Negative Breast Cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by a lack of key hormone receptors in tumor cells. As there are limited treatment options for these patients, it is crucial to understand the underlying mechanisms by which TNBC constantly evolves and evades treatments. In this regard, the pervasive nature of transcription provides a potential reservoir of transcripts, including both coding and noncoding, that TNBC leverages to sustain a proliferative advantage and support tumor growth. TNBC is affected by energy sources such as glucose, which can have a profound impact on gene expression regulation mediated by various molecules, including noncoding RNAs, at the cellular level. In this study, we demonstrate that glucose modulates the gene expre

SUBMITTER: Reid VA 

PROVIDER: S-EPMC12753515 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature