Assessing the radiation-induced bystander effect in radionuclide therapy using targeted radiopharmaceuticals.

ABSTRACT:

Background

Radiation-induced biologic bystander effects (RIBBEs) where non-irradiated cells display radiation like responses are well established in the context of external beam radiotherapy. However, their presence and characteristics in radionuclide therapy have been explored in only a limited number of studies. With the growing application of radionuclide therapy, this study was designed to investigate RIBBEs using a targeting agent labeled with three different types of emitters, aiming to quantify the varying biological effects attributable to each radionuclide and to devise strategies for achieving maximum therapeutic effect.Trastuzumab antibody targeting human epidermal growth factor receptor 2 (HER2) was labeled with radionuclides of varying energy profile; Y-90 (β^-

SUBMITTER: Sharma R 

PROVIDER: S-EPMC12753616 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature