Prognostic nutritional indices predict 60 day mortality in ICU patients with sepsis.

ABSTRACT: Sepsis is frequently accompanied by severe metabolic disturbances and malnutrition, with nutritional status being an important modifiable factor affecting patient outcomes. The Prognostic Nutritional Index (PNI) and the Geriatric Nutritional Risk Index (GNRI) are multidimensional tools for assessing nutritional status. However, the association between PNI/GNRI and 60-day mortality in patients with sepsis remain inadequately elucidated. This study aimed to evaluate the value of PNI and GNRI for predicting the mortality risk in sepsis based on analysis of data from the MIMIC-IV database. A total of 1649 patients with sepsis were enrolled and stratified into tertiles of PNI and GNRI. We performed Kaplan-Meier survival analysis, multivariate Cox regression analysis, restricted cubic spline (RC

SUBMITTER: Fang J 

PROVIDER: S-EPMC12753698 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature