Micro RNA miR-726-3p targets CYB5A in Hen ovaries to modulate granulosa cell proliferation and differentiation.

ABSTRACT: Follicular development is closely related to poultry egg production. Granulosa cells (GCs) are important components of follicles and vital for follicular selection and hierarchical development. Previous studies demonstrated that miRNAs play a key role in controlling follicular development and atresia. However, biological effects and mechanism of action of miR-726-3p on GC proliferation and differentiation of hen ovaries remain poorly understood. In this study, we compared miRNA profiles in larger white follicles (LWF), along with large (LYF) and small yellow follicles (SYF), to identify target genes related to follicular development. Nine cDNA libraries were constructed, in which 61 miRNA-linked genes were significantly differentially expressed (DE). MiR-726-3p was the most crucial co-DE m

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12753754 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature