Essential oils from Artemisia judaica, Ruta graveolens and Salvia palaestina with antiradical, cytotoxic and AMPA receptor-modulatory activities.

ABSTRACT: Essential oils (EOs) from the leaves of Artemisia judaica, Ruta graveolens, and Salvia palaestina were analyzed for their phytochemical composition and their antiradical, cytotoxic, and neuromodulatory activities. Using microwave-ultrasonic technology, EOs were extracted from S. palaestina, A. judaica, and R. graveolens, and their antiradical activity (via DPPH assay), cytotoxicity, and neuromodulatory effects (using whole-cell patch-clamp recordings) were evaluated. The main compounds that were explored by GC-MS analysis include piperitone and carvacrol in A. Judaica, 2-undecanone in R. graveolens, and carvacrol in S. palaestina. S. palaestina exhibited the greatest antiradical effect with a 50% inhibition concentration of 8.30 µg/mL. Cytotoxicity tests showed that these EOs express dose-

SUBMITTER: Qneibi M 

PROVIDER: S-EPMC12753767 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature