Cortical activation and functional connectivity during verbal fluency task in patients with chronic insomnia: a multi-channel fNIRS study.

ABSTRACT: Chronic insomnia disorder (CID) is associated with verbal fluency deficits linked to abnormal prefrontal activation. This multichannel functional near-infrared spectroscopy (fNIRS) study compared prefrontal hemodynamic responses and functional connectivity during verbal fluency tasks (VFT) in 81 CID patients versus 100 healthy controls (HC). Cortical activation patterns and interregional connectivity were analyzed using general linear modeling and correlation matrices. CID patients exhibited significantly reduced bilateral prefrontal activation (p < 0.01), particularly in the left inferior frontal gyrus (IFG), middle frontal gyrus (MFG), and superior frontal gyrus (SFG), alongside 32-45% weaker functional connectivity compared to HC. Activation in left IFG correlated negatively with sleep

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12753792 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature