Elemental and biomolecular changes in serum as indicators of SPION action in the body: analysis using TXRF, FTIR and Raman spectroscopy.

ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPION) have enormous potential for the use in medical diagnostics and therapy, including theranostics and personalized medicine. However, their clinical implementation remains limited, partly due to insufficient understanding of their systemic biocompatibility, metabolism and long-term physiological impact. In this study, we investigated the molecular and elemental alterations in blood serum following SPION administration, with the goal of identifying sensitive biomarkers of nanoparticle-induced biological responses. PEGylated SPION with a 10 nm magnetite core were intravenously administered to male and female Wistar rats. Serum samples were collected at 2 h, 24 h, and 7 days post-injection. A multimodal analytical approach was employed, combinin

SUBMITTER: Wilk A 

PROVIDER: S-EPMC12753794 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature