Transthoracic echocardiography of left ventricular underfilling improves risk stratification in pulmonary arterial hypertension.

ABSTRACT: Pulmonary arterial hypertension (PAH) is characterized by right ventricular (RV) adaptation to elevated afterload. However, the prognostic value of left ventricular (LV) underfilling in response to RV volume overload is unknown. We aimed to investigate the prognostic value of LV underfilling in PAH. Does Trans-thoracic echocardiography (TTE) assessed LV underfilling enhance prognostic accuracy in PAH beyond existing models such as REVEAL-Lite 2.0 and REVEAL-ECHO? 270 patients with PAH were prospectively enrolled. LV underfilling was defined as the LV volume-to-mass (V/M) ratio of < 0.8 ml/g. TTE and hemodynamic parameters were compared between patients with and without LV underfilling. The Cox regression model identified LV parameters significantly predictive of survival. The current LV mo

SUBMITTER: Ahmad A 

PROVIDER: S-EPMC12753818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature