Competitive Viral Interference Controls Arbovirus Co-Transmission in Aedes aegypti.

ABSTRACT: Viruses are the primary etiological agents responsible for numerous mosquito-borne diseases, which pose a global threat to humans and their carriers. In this study, we conducted a comprehensive analysis of the simultaneous presence of different viruses in a total of 237 transcriptomic datasets derived from Aedes aegypti (AA), obtained from the SRA and ENA databases to understand its impact on transmission of arboviruses such as Dengue, Zika, and Chikungunya to humans. We investigated the co-occurrence patterns of 21 distinct viruses, encompassing 52 isolates, which are known to be transmitted by mosquitoes. In addition, we used heatmaps, correlation coefficients, estimated count values, and differential gene expression to examine the viral abundance and the significant genes involved in vi

SUBMITTER: Balakrishnan B 

PROVIDER: S-EPMC12753823 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature