Longitudinal brain connectivity changes associated with successful smoking cessation.

ABSTRACT:

Background

Tobacco smoking continues to be a leading cause of preventable morbidity and mortality globally, with the success rate of unaided cessation remaining consistently low. Understanding the neurobiological mechanisms of smoking cessation is crucial for improving quit rates. However, there has been a lack of studies examining brain network changes associated with smoking cessation over time. In this study, we aimed to investigate longitudinal changes in the functional connectivity (FC) of large-scale brain networks underlying smoking cessation outcomes using resting-state functional magnetic resonance imaging (fMRI).

Methods

A total of 98 treatment-seeking smokers participated in a 5-week cessation program and underwent resting-state fMRI scans before and after the int

SUBMITTER: Im JJ 

PROVIDER: S-EPMC12753871 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature