Urantide alleviates lipopolysaccharide/D-galactosamine-induced acute liver failure through upregulating carboxylesterase1f in mice.

ABSTRACT:

Aims

To investigate the effect of urotensin II(UII)/UII receptor(UT) on hepatic carboxylesterase1f(Ces1f) expression in acute liver failure(ALF) mice.

Methods

ALF was induced in male Balb/c mice using lipopolysaccharide (LPS)/D-galactosamine (D-GalN) i.p. after a tail vein injection of Urantide, a specific antagonist of UT receptor. Liver tissues were collected at 0-12h to detect UII and Ces1f mRNA levels in ALF mice. Mice were divided into four groups (n=6 each group): (A) Urantide(-), LPS/D-GalN(-), (B) Urantide(+), LPS/D-GalN(-), (C) Urantide(-), LPS/D-GalN(+), and (D) Urantide(+), LPS/D-GalN(+). Liver tissues were collected at 6 h after a challenge of LPS/D-GalN. Time-depended levels were observed of hepatic UII and Ces1f mRNA over a period of

SUBMITTER: Yang W 

PROVIDER: S-EPMC12753892 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature