The mechanistic role of gitogenin as a treatment for laryngeal cancer: a network pharmacology and experimental analysis.

ABSTRACT:

Objective

Laryngeal cancer (LC) is a significant and persistent therapeutic challenge worldwide. Gitogenin (GIT), a naturally occurring saponin, has demonstrated anticancer activity in lung cancer. However, its potential effects on LC remain unclear. This study aimed to elucidate the therapeutic efficacy of GIT and the mechanisms through which it acts against LC by integrating network pharmacology analysis with experimental validation.

Methods

Potential targets of GIT were established using the PharmMapper database, while LC-associated genes were retrieved from the GeneCards database. Common targets between GIT and LC were determined, and the top 20 genes were chosen for protein-protein and gene-gene interaction (PPI and GGI) network construction. Functional enrichment analy

SUBMITTER: Fu Z 

PROVIDER: S-EPMC12753904 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature