Interaction Effect of Depression and Hypertension on Nephrotoxicity Among Persons Living With HIV: A Cross-Sectional Study.

ABSTRACT:

Background

The goal of antiretroviral therapy will not be achieved without addressing Human Immunodeficiency Virus (HIV) comorbidities, including depression, hypertension, and nephrotoxicity among people living with HIV (PLWH). This study was conducted to assess the interaction effect of depression and hypertension on nephrotoxicity among PLWH.

Methods

The study employed a cross-sectional study design. Data were collected from May to June 2022. The main outcome was nephrotoxicity, while depression and hypertension were considered as exposure factors. Confounders were identified through the directed acyclic graph and were controlled using the propensity score matching procedure. We estimated the causal association from the interactions by using weighted logistic regression.

SUBMITTER: Tetteh J 

PROVIDER: S-EPMC12754264 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature